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The broad spectrum
ß-lactamase inhibitor
Inhibits all clinically
significant
ß-lactamases
Does not induce chromosomally mediated ß-lactamase production
Reduces MICs of cefoperazone by 4 to 28 fold
Expands the spectrum of activity of ampicillin / cefoperazone
ß-lactamases
Even BIGGER threat
93%
Anaerobes
40%
Gram -ve aerobes
23%
Gram +ve aerobes
Found producing ß-lactamases
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